p115 Rho GEF

MGI MGI:1353510

Expression Profile

  MGI  SwissProt  Affy  Unigene  RefSeq  LocusLink  GeneOntology  

MGI  Top

ID: MGI:1353510
Symbol: Arhgef1
Name: Rho guanine nucleotide exchange factor (GEF) 1

SwissProt  Top

ID: ARH1_MOUSE
Accession: Q61210, O89074, Q80YE8, Q80YE9, Q91VL3
Name: ARHGEF1
Species: Mus musculus
Protein: Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis like 2) (Lbc’s second cousin).
Functions: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity.

Affy  Top

ID: 1421164_a_at
ID: 98001_at
ID: U58203_s_at

Unigene  Top

ID: Mm.3181
Title: Rho guanine nucleotide exchange factor (GEF) 1
Gene: Arhgef1
Cytoband: 7 A2

RefSeq  Top

ID: NM_008488

LocusLink  Top

ID: 16801
Symbol: Arhgef1
Name: Rho guanine nucleotide exchange factor (GEF) 1

GeneOntology  Top

ID: 0005089
Name: Rho guanyl-nucleotide exchange factor activity
ID: 0007266
Name: Rho protein signal transduction

Expression Profile  Top

Gene ID U58203_s_at
Quiescence-Term-18
HOPACH Clusters
Quiescence-Term-Post
Quiescence-Term-14
Quiescence-T-P 2fold
Postpartum
non-pregnant avg 870.95
14days avg 825.41
14days fold -1.06
16days avg 900.81
16days fold 1.03
16v14 fold 1.09
17days avg 902.15
17days fold 1.04
17v16 fold 1
18days avg 831.02
18days fold -1.05
18v14 fold 1.01
18v16 fold -1.08
18v17 fold -1.09
6hrs avg 937.76
6hrs fold 1.08
6v18 fold 1.13
24hrs avg 1137.99
24hrs fold 1.31
24v18 fold 1.37
24v6 fold 1.21
GenBank U58203
GenMAPP ID Q91VL3
Gene_Symbol Arhgef1
MapLocation 7 A3
f-rawp 0.0041
f-adjp 0.9998
gestation >20p 0
post>20p 1
gestation<-20p 0
post<-20p 0
Sum all 1
np fold-log 0
14d fold-log -0.08
16d fold-log 0.05
17d fold-log 0.05
18d fold-log -0.07
6hrs fold-log 0.11
24hrs fold-log 0.39
final cluster 3.00E+15
main cluster 30000000
2nd level cluster 30
main/medoid order 1924
Mediod no
total in cluster 471
final order 1746
HOPACH Pattern Down Quiescence/Up Postpartum
Abs-main cluster 70000
Abs final order 4151
Abs-Pattern NULL
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